One of the most popular diets for what you want to lose weight is a low carbohydrate, which consists of reducing carbohydrate consumption and increasing healthy protein and fat consumption. Although it is, in fact, to weight loss, this type of Diera can earn or rich from developing colorectal cancer, according to a new study published on the last day 3 in the journal Microbiology of Nature.
No WorkResearchers have examined the effects of three non -developmental colorectal cancer diets: a conventional diet, latest carbohydrate band and a western style, rich in fat and sugar.
According to the researchers, a single strain of Bacteria E. coli, when associated with a low carbohydrate and restricted diet in soluble fibers, stimulates polyps growth in the colon. These polyps can be precursors of cancer.
“Semper colorectal cancer was considering as a sendão caused by a series of DIF factors. In a statement. “Our question was: an influence of the diet is a capacity of bacteria specific to cause Canter?”
To answer this question, the researchers conducted preclinical studies-done on animals and laboratory before being tested on humans-using the three previously described diets and models that were colonized with one of the three bacterial species that were previously associated with colorectal cancer.
According to the study, only the low carbohydrate diet combined with an E. coli strain led to the colorectal cancer denenvilot. This strain produces the compound bolibactin, which damages DNA.
The peses also have a fiber -deficient diet increased the inflammation in the gut and alters a community of microbes that Normand reside do not reside in the organ. This created an abuse that allowed an E. coli colibactin -producing E. colla to prosper in the gut.
In addition, low carb diets were associated with a thinner layer of mucus separating intestinal microbes from colon epithelial cells. A layer of mucus acts as a protective shield between as bacteria in the intestine and as cells below. Ontanto, with a weakened barrier, more colibactin could reach as colon cells and the tumor growing.
The researchers also observed that these effects were especially stronger in genegic mutations that made it difficult to consist of the damaged DNA. This type of mutation is common in the case of colorectal-e-estead cancer that 15% gives tumors tumors have mutajes in incompatibility repair gene.
These mutations are also a basis of lynch syndrome, a genetic condition that increases significantly the risk of a weight developing certain types of cancer, including colorectal cancer.
As discoveries suggest that avoiding a low carbohydrate diet – or taking specific antibiotics to get rid of colibactin -producing bacteries – can reduce the risk of colorectal canchcerine, main in Lynych syndrome patients.
Researchers now explore whether long -term use of a probactic that produces bolibactin is safe for people with a condition or that is to estimate following a low diet.
The study also showed that adding soluble fibers a low and low carbohydrate diet to lower Nívis of E. coli causing cancer, less tumors and less damage to DNA.
“We supplemented fiber and saw this reduced the effects of Diera Low-Carb,” says Bhush Thakur, study leader. “Now we are trying to decline which fiber sources are most beneficial and which are less beneficial.”
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